African Descent and Glaucoma Evaluation Study

ID#: NCT00221923

Age: 18 years - 66+

Gender: All

Healthy Subjects: Accepts Healthy Volunteers

Recruitment Status: Enrolling by invitation

Start Date: September 01, 2002

End Date: July 01, 2022

Summary: According to the National Eye Institute, Glaucoma affects about three million Americans. Among Blacks in the United States, open- angle glaucoma is the leading cause of irreversible visual loss. Glaucoma is four times more likely to develop in Blacks than in Whites. This is a prospective longitudinal, multi- site observational cohort study designed to obtain visual function and optic nerve structure data on eyes of Black and White Americans. The investigators will evaluate the relationship between changes in the structure of the eye and the vision loss caused by glaucoma.This is the first study where both populations are matched for quality of care and equal access to care.
Eligibility:

Inclusion Criteria:

- Open angles

- Best-corrected acuity of 20/40 or better

- Spherical refraction within + 5.0 D, and cylinder within + 3.0 D with plus OR minus cylinders

- ≥ 18 years old

- A family history of glaucoma is allowed

- Ability to obtain adequate or better quality stereophotographs

- Ability to do reliable standard Humphrey 30-2 or 24-2 visual fields

- Participants with glaucoma or at risk for glaucoma or healthy controls

Exclusion Criteria:

- History of intraocular surgery (except uncomplicated cataract or glaucoma surgery)

- Problems other than Glaucoma affecting color vision

- Non glaucomatous secondary causes of elevated IOP ( e.g. iridocyclitis, trauma)

- Other intraocular eye disease

- Other diseases affecting visual field (e:g pituitary lesions, demyelinating diseases, HIV+ or AIDS, or diabetic retinopathy) with medications known to affect visual field sensitivity

- Problems other than Glaucoma affecting color vision
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